Probiotic for diabetes control
HAC01™
- Brand nameHAC01 Lactobacillus plantarum HAC01
- OriginKorea
- Strong point
Reduction of post-meal blood sugar and glycated hemoglobin (HbA1c) confirmed by human body’s clinical trial, Patents registered in USA, China and Korea, 4 SCI papers
Result of Clinical Trial
- Jeonbuk National University Hospital's clinical trial support center for functional foods
- 40 subjects, 8 weeks, random, double-blind, placebo
Feature
| Item |
Content |
Remarks |
| Origin |
Traditional fermented food (White Kimchi) |
After completing the whole-genome sequencing, registered on the site the National Institutes of Health(NCBI) |
| Safety |
Antibiotics safety / No biogenic amine / No hemolysis |
Passed the antibiotic sensitivity test based on the EFSA (European Food Safety Authority) |
| Basic Functionalities |
Bile salt hydrolase / Peroxide production |
H2O2 (antibacterial substance) production and BSH (biliary acid catabolic enzyme) production confirmed |
| Acid resistance, Bile resistance |
pH 2.0~3.0, survivable in the presence of bile acids |
The conditions to live to the intestines confirmed |
| Functionalities |
- Through the animal experiment by using high-fat-fed-induced mice, body fat reducing activation and reducing effect of blood sugar confirmed
- Through human body application tests, the degradation effects of blood sugar and glycated hemoglobin(HbA1c) for 2 hours later after meal confirmed
|
- Increase glucose uptake and fatty acid oxidation to muscle tissue, and reduce gluconeogenesis in liver tissue, contributing to lower blood sugar levels
- Participate in increasing insulin secretion through the recovery effect of pancreatic beta cells
- Changes in short chain fatty acids and increased butyric acid through intestinal microbiome control contribute to lowering blood sugar
- In the human body application test, blood sugar was p=0.045 and glycated hemoglobin was p=0.030 for 2 hours later after meals, which were significantly lower than the control group
|